Controlling Evolution: Predicting and Engineering the Future of Life

Controlling Evolution Predicting and Engineering the Future of Life

Scientists are pushing the boundaries of evolutionary biology, seeking to control the process of evolution itself.

Evolution has long fascinated scientists, who have sought to unravel its mysteries and understand its underlying principles. While predicting how evolution happens has been a goal for many biologists, the focus has now shifted towards a more ambitious endeavor: controlling the process itself. This may sound like science fiction, but examples from our past, such as artificial selection in agriculture, show that controlling evolution is not entirely out of reach. Scientists are now exploring ways to dictate how evolution occurs at the molecular level and exert direct control over the reproductive process. This article delves into the fascinating world of directed evolution, the potential for controlling evolution, and the ethical considerations that come with such advancements.

Directed Evolution: Engineering New Biomolecules

The 2018 Nobel Prize in Chemistry recognized the groundbreaking work on directed evolution, a method that allows scientists to engineer new biomolecules. Frances Arnold, one of the winners, pioneered a technique to mutate proteins in the laboratory and measure their functionality. By selectively mutating and selecting proteins with improved function, scientists are able to control how evolution happens at the molecular level. This approach, akin to the selective breeding of dogs, demonstrates that we can manipulate evolution to achieve desired outcomes.

Steering Evolution Away from Resistance

In the fight against antibiotic-resistant pathogens, scientists have proposed using antibiotics in a specific order to steer evolution away from creating resistance. This strategy takes advantage of the trade-offs in biological systems, where adaptation often comes with costs. Similarly, in cancer treatment, oncologists are leveraging our understanding of cancer at the molecular level to steer cancer cells towards susceptibility to certain drugs. By exploiting the concept of “collateral sensitivity,” where resistance to one drug may make cancer cells more susceptible to others, scientists are attempting to control the evolutionary process in a medical context.

Generalizing Evolutionary Control

Building on these approaches, scientists are now applying ideas from quantum physics to shift populations towards predetermined goals. By using a method called counterdiabatic driving, researchers can potentially drive populations of malaria parasites towards more easily treatable strains. This multidisciplinary approach, involving physicians, computer scientists, and physicists, showcases the potential for controlling evolution in various systems beyond proteins and pathogens.

Microbiome Control for Improved Health

The microbiome, the complex community of microorganisms that inhabit our bodies, is another area where directed evolution is being employed. By understanding how different microbes interact and using new microbial techniques, scientists aim to control microbial communities in the microbiome. The goal is to steer the composition of the microbiome towards one associated with improved health outcomes. While still in its early stages, this research holds promise for personalized medicine and the treatment of various diseases.


The ability to control evolution, while still limited, is no longer confined to the realm of science fiction. Through directed evolution and other innovative approaches, scientists are gaining the ability to manipulate the evolutionary process at the molecular level. However, the ethical considerations surrounding such advancements cannot be ignored. The cautionary tales of past attempts at controlling evolution, such as eugenics, remind us of the dangers of overzealous applications. It is crucial to recognize our limits and approach evolutionary control with a balanced perspective. While the future of controlling evolution holds great potential, it is essential to navigate this path with caution, always mindful of the complexities and uncertainties inherent in the process of life itself.